Computational Biologist
Phone: (309) 681-6243
Fax: (309) 681-6672
Room 1137B
1815 N University St.
Peoria IL 61604
Hye-Seon Kim has worked as computational biologist at NCAUR since May 2020. She received her B.S. in Applied Biology and Microbiology from Chungnam National University in South Korea, her M.S. in Biotechnology from Seoul National University, and her Ph.D. in Plant Pathology from the Pennsylvania State University. During her graduate research, she developed PCR-based molecular markers to identity two groups of the fungus Fusarium that differ in mycotoxin production phenotypes, elucidated a key molecular cellular mechanism in plant-pathogen interactions, and found the loss of a cyclic AMP-dependent protein kinase reduced growth, virulence, and root pathogenesis in Fusarium. In her postgraduate research, she used molecular genetic tools and advanced microscopy imaging techniques to demonstrate how some calcium signaling proteins affect growth, pathogenesis, and mycotoxin production in Fusarium. In 2016, she began a post doc at NCAUR and studied the distribution and identification of genes responsible for biosynthesis of mycotoxins and other secondary metabolites in the genus Fusarium. Currently, she works on multi-omics studies to develop novel solution to Fusarium mycotoxin contamination problems. The goals of her are to determine the genetic and metabolic diversity of mycotoxigenic fungi and to elucidate critical components of the molecular interaction between the fungi and their plant hosts. She uses computational biology, bioinformatics, comparative genomics, and molecular biology approaches to achieve these objectives.
Click to Access my Publications
Improving Food Safety by Controlling Mycotoxin Contamination and Enhancing Climate Resilience of Wheat and Barley In-House Appropriated (D) Accession Number:438642 Innovative Food and Feed Safety Research to Eliminate Mycotoxin Contamination in Corn and other Crops In-House Appropriated (D) Accession Number:438647
will take you to the publication reprint.)
-(Peer Reviewed Journal)
Proctor, R.H., Hao, G., Kim, H.-S., Whitaker, B.K., Laraba, I., Vaughan, M.M., McCormick, S.P. 2022. A novel trichothecene toxin phenotype associated with horizontal gene transfer and a change in gene function in Fusarium. Toxins. 15(1). Article 12. https://doi.org/10.3390/toxins15010012.
-(Peer Reviewed Journal)
O'Donnell, K., Grafenhan, T., Laraba, I., Busman, M., Proctor, R.H., Kim, H.-S., Wiederhold, N.P., Geiser, D.M., Seifert, K.A. 2022. Fusarium abutilonis and F. guadeloupense, two novel species in the Fusarium buharicum clade supported by multilocus molecular phylogenetic analyses. Mycologia. 114(4):682-696. https://doi.org/10.1080/00275514.2022.2071563.
-(Peer Reviewed Journal)
Brown, D.W., Kim, H.-S., McGovern, A.E., Probyn, C.E., Proctor, R.H. 2022. Genus-wide analysis of Fusarium polyketide synthases reveals broad chemical potential. Fungal Genetics and Biology. 160. Article 103696. https://doi.org/10.1016/j.fgb.2022.103696.
-(Review Article)
O'Donnell, K., Whitaker, B.K., Laraba, I., Proctor, R.H., Brown, D.W., Broders, K., Kim, H.-S., McCormick, S.P., Busman, M., Aoki, T., Torres-Cruz, T.J., Geiser, D.M. 2022. DNA sequence-based identification of Fusarium: A work in progress. Plant Disease. 106(6):1597-1609. https://doi.org/10.1094/PDIS-09-21-2035-SR.
-(Peer Reviewed Journal)
Johnson, E.T., Kim, H., Tian, M., Dudai, N., Tal, O., Gonda, I. 2021. Dual transcriptional analysis of Ocimum basilicum and Peronospora belbahrii in susceptible interactions. Plant Gene. 29. Article 100350. https://doi.org/10.1016/j.plgene.2021.100350.
-(Database / Dataset)
Torres-Cruz, T.J., Whitaker, B.K., Proctor, R.H., Broders, K., Laraba, I., Kim, H.-S., Brown, D.W., O'Donnell, K., Estrada-Rodriguez, T.L., Lee, Y.-H., Cheong, K., Wallace, E.C., McGee, C.T., Kang, S., Geiser, D.M. 2022. FUSARIUM-ID v.3.0: An updated, downloadable resource for Fusarium species identification. Plant Disease. https://doi.org/10.1094/PDIS-09-21-2105-SR.
-(Peer Reviewed Journal)
Guttierrez, S., McCormick, S.P., Cardoza, R.E., Kim, H.-S., Yugueros, L.L., Vaughan, M.M., Carro-Huerga, G., Busman, M., Saenz de Miera, L.E., Jaklitsch, W.M., Zhuang, W.-Y., Wang, C., Casquero, P.A., Proctor, R.H. 2022. Distribution, function, and evolution of a gene essential for trichothecene toxin biosynthesis in Trichoderma. Frontiers in Microbiology. 12. Article 791641. https://doi.org/10.3389/fmicb.2021.791641.
-(Pre-print Publication)
Johnson, E.T., Kim, H., Tian, M., Dudai, N., Tal, O., Gonda, I. 2021. Dual transcriptional analysis of Peronospora belbahrii and Ocimum basilicum in susceptible interactions. bioRxiv. 2021. Article 457810. https://doi.org/10.1101/2021.09.07.457810.
Johnson, E.T., Kim, H., Doehring, M.E., Tian, M., Gonda, I., Tal, O., Dudai, N. 2021. Dual transcriptome analysis of the susceptible interaction between basil and Peronospora belbahrii. Meeting Abstract. [abstract].
-(Book / Chapter)
Kim, H.-S., Park, S.-Y., Kang, S., Czymmek, K.L. 2022. Time-lapse imaging of root pathogenesis and fungal proliferation without physically disrupting roots. In: Coleman, J., editor. Fusarium wilt. Methods in Molecular Biology, vol 2391. New York, NY: Humana. p. 153-170. https://doi.org/10.1007/978-1-0716-1795-3_13.
-(Review Article)
Kang, S., Lumactud, R., Li, N., Bell, T.H., Kim, H.-S., Park, S.-Y., Lee, Y.-H. 2021. Harnessing chemical ecology for environment-friendly crop protection. Phytopathology. 111(10):1697-1710. https://doi.org/10.1094/PHYTO-01-21-0035-RVW.
Hao, G., Naumann, T.A., Chen, H., Bai, G., Tiley, H.C., McCormick, S.P., Tian, B., Trick, H.N., Kim, H.-S., Proctor, R. 2021. Host-induced silencing of a Fusarium graminearum effector enhances wheat resistance to Fusarium Head Blight. [abstract].
-(Peer Reviewed Journal)
Geiser, D.M., Al-Hatmi, A., Aoki, T., Arie, T., Balmas, V., Barnes, I., Bergstrom, G.C., Bhattacharyya, M.K., Bloomquist, C.L., Bowden, R.L., Brankovics, B., Brown, D.W., Burgess, L.W., Bushley, K., Busman, M., Cano-Lira, J.F., Carillo, J.D., Chang, H., Chen, C., Chen, W., Chilvers, M., Chulze, S., Coleman, J.J., Cuomo, C.A., De Beer, W., De Hoog, S., Del Castillo-Munera, J., Del Ponte, E.M., Dieguez-Uribeondo, J., Di Pietro, A., Edel-Hermann, V., Elmer, W.H., Epstein, L., Eskalen, A., Esposto, M., Everts, K.L., Fernandez-Pavia, S.P., Ferreira Da Silva, G., Foroud, N.A., Fourie, G., Frandsen, R., Freeman, S., Freitag, M., Frenkel, O., Fuller, K.K., Gagkaeva, T., Gardiner, D.M., Glenn, A.E., Gold, S.E., Gordon, T., Gryzenhout, M., Guarro, J., Gugino, B.K., Gutierrez, S., Kim, H., Kistler, H.C., Lofton, L., Laraba, I., Martin, F.N., Mccormick, S.P., O Donnell, K., Proctor, R., Rehner, S.A., Vaughan, M.M., Ward, T.J. 2021. A monophyletic Fusarium that includes the Fusarium solani species complex is strongly supported by a 19-gene phylogenomic analysis. Phytopathology. https://doi.org/10.1094/PHYTO-08-20-0330-LE.
-(Review Article)
O'Donnell, K., Al-Hatmi, A.M.S., Aoki, T., Brankovics, B., Cano-Lira, J.F., Coleman, J.J., de Hoog, G.S., Di Pietro, A., Frandsen, R.J., Geiser, D.M., Gibas, C.F., Kim, H.-S., Kistler, H.C., Laraba, I., Proctor, R.H., Ward, T.J., et al. 2020. No to Neocosmospora: Phylogenomic and practical reasons for continued inclusion of the Fusarium solani species complex in the genus Fusarium. mSphere. 5(5). Article e00810-20. https://doi.org/10.1128/mSphere.00810-20.
Kim, H.-S., McCormick, S.P., Busman, M., Hao, G., Lohmar, J.M., Vaughan, M.M., Brown, D.W., Proctor, R. 2020. Comparative genomic, transcriptomic and functional analyses provide new insights into diversity, distribution and evolution of natural products produced by the agriculturally important fungal genus Fusarium. American Chemical Society Abstracts. [abstract].
-(Peer Reviewed Journal)
Kim, H.S., Lohmar, J.M., Busman, M., Brown, D.W., Naumann, T.A., Divon, H.H., Lysoe, E., Uhlig, S., Proctor, R.H. 2020. Identification and distribution of gene clusters required for synthesis of sphingolipid metabolism inhibitors in diverse species of the filamentous fungus Fusarium. Biomed Central (BMC) Genomics. 21:510. https://doi.org/10.1186/s12864-020-06896-1.
-(Peer Reviewed Journal)
Gargouri, S., Balmas, V., Burgess, L., Paulitz, T., Laraba, I., Kim, H.-S., Proctor, R.H., Busman, M., Felker, F.C., Murray, T., O'Donnell, K. 2020. An endophyte of Macrochloa tenacissima (esparto or needle grass) from Tunisia is a novel species in the Fusarium redolens species complex. Mycologia. 112(4):792-807. https://doi.org/10.1080/00275514.2020.1767493.
Brown, D.W., Kim, H.-S., Busman, M., Proctor, R. 2020. Genus-wide analysis of Fusarium polyketide synthases uncovers broad natural product potential [abstract].
Proctor, R., Kim, H.-K., Laraba, I., Hao, G., Vaughan, M.M., Naumann, T.A., Brown, D.W., Ward, T.J., O'Donnell, K., Busman, M., McCormick, S.P. 2020. Evolution of secondary metabolite diversity in fungi [abstract].
-(Peer Reviewed Journal)
Hao, G., Bakker, M.G., Kim, H.-S. 2020. Enhanced resistance to Fusarium graminearum in transgenic Arabidopsis plants expressing a modified plant thionin. Phytopathology. 110(5):1056-1066. https://doi.org/10.1094/PHYTO-12-19-0447-R.
Hao, G., McCormick, S.P., Naumann, T.A., Kim, H.-S., Proctor, R. 2019. The effector FgNls1 is required for full virulence of Fusarium graminearum [abstract].
-(Peer Reviewed Journal)
Brown, D.W., Villani, A., Susca, A., Moretti,A., Hao, G., Kim, H.-S., Proctor, R.H., McCormick, S.P., 2019. Gain and loss of a transcription factor that regulates late trichothecene biosynthetic pathway genes in Fusarium. Fungal Genetics and Biology. 136:103317. https://doi.org/10.1016/j.fgb.2019.103317.
-(Peer Reviewed Journal)
Laraba, I., Kim, H.-S., Proctor, R.H., Busman, M., O'Donnell, K., Felker, F.C., Aime, M.C., Koch, R.A., Wurdack, K.J. 2019. Fusarium xyrophilum, sp. nov., a member of the Fusarium fujikuroi species complex recovered from pseudoflowers on yellow-eyed grass (Xyris spp.) from Guyana. Mycologia. 112(1):39-51. https://doi.org/10.1080/00275514.2019.1668991.
Kim, H., Vaughan, M.M., Busman, M., McCormick, S.P., Brown, D.W., Proctor, R. 2019. Computational and genomic approaches for natural product discovery in the fungus Fusarium [abstract].
Laraba, I., Kim, H.-S., Vaughan, M.M., Busman, M., Proctor, R.H., O'Donnell, K., Aime, M.C., Koch, R.A., Wurdack, K.J. 2019. A novel Fusarium induces putative pseudoflowers on yellow-eyed grass (Xyris spp.) in Guyana [abstract].
Hao, G., Bakker, M.G., Kim, H.-S. 2019. Transgenic Arabidopsis expressing a modified plant thionin enhanced resistance to Fusarium graminearum [abstract].
-(Peer Reviewed Journal)
Montoya-Martinez, A.C., Rodriguez-Alvarado, G., Fernandez-Pavia, S.P., Proctor, R.H., Kim, H.-S., O'Donnell, K. 2019. Design and validation of a robust multiplex polymerase chain reaction assay for MAT idiomorph within the Fusarium fujikuroi species complex. Mycologia. 111(5):772-781. https://doi.org/10.1080/00275514.2019.1649956.
-(Peer Reviewed Journal)
Cardoza, R.E., McCormick, S.P., Lindo, L., Kim, H.-S., Olivera, E.R., Nelson, D.R., Proctor, R.H., Gutierrez, S. 2019. A cytochrome P450 monooxygenase gene required for biosynthesis of the trichothecene toxin harzianum A in Trichoderma. Applied Microbiology and Biotechnology. 103(19):8087-8103. https://doi.org/10.1007/s00253-019-10047-2.
Hao, G., Kim, H., Proctor, R., McCormick, S.P. 2019. Fusarium graminearum effector targeting plant nucleus is associated with wheat head blight [abstract].
Laraba, I., Kim, H.-S., Vaughan, M.M., Busman, M., Proctor, R., O'Donnell, K., Aime, C.M., Wurdack, K.J. 2019. A novel Fusarium induces putative pseudoflowers on yellow-eyed grass (Xyris spp.) in Guyana [abstract].
Brown, D.W., Kim, H.-S., Proctor, R. 2019. Oxylipins differentially impact Fusarium gene expression [abstract].
Villani, A., Proctor, R., Kim, H.-S., Brown, D.W., Amatulli, T., Logrieco, A.F., Moretti, A., Susca, A. 2019. Vertical inheritance, gene loss, horizontal gene transfer and the content of secondary metabolite biosynthetic genes in the Fusarium incarnatum-equiseti species complex [abstract].
Proctor, R., McCormick, S.P., Lindo, L., Cardoza, R.E., Kim, H.-S., Brown, D.W., Busman, M., Gutierrez, S. 2019. Convergence and divergence of gene function during the evolutionary history of trichothecene biosynthesis [abstract].
-(Peer Reviewed Journal)
Villani, A., Proctor, R.H., Kim, H.-S., Brown, D.W., Logrieco, A.F., Amatulli, M.T., Moretti, A., Susca, A. 2019. Variation in secondary metabolite production potential in the Fusarium incarnatum-equiseti species complex revealed by comparative analysis of 13 genomes. BMC Genomics. 20:314. https://doi.org/10.1186/s12864-019-5567-7.
-(Peer Reviewed Journal)
Hao, G., McCormick, S., Vaughan, M.M., Naumann, T.A, Kim, H.-S., Proctor, R., Kelly, A., Ward, T.J. 2019. Fusarium graminearum arabinanase (Arb93B) enhances wheat head blight susceptibility by suppressing plant immunity. Molecular Plant-Microbe Interactions. https://doi.org/10.1094/MPMI-06-18-0170-R.
-(Peer Reviewed Journal)
Xue, Z., Cao, Z., Liu, X., Kim, H.-S., Proctor, R.H., O'Donnell, K. 2019. Maternal mitochondrial inheritance in two Fusarium pathogens of prickly ash (Zanthoxylum bungeanum) in northern China. Mycologia. 111(2):235-243. https://doi.org/10.1080/00275514.2018.1562269.
-(Peer Reviewed Journal)
Lindo, L., McCormick, S.P., Cardoza, R.E., Kim, H.-S., Brown, D.W., Alexander, N.J., Proctor, R.H., Gutierrez, S. 2018. Role of Trichoderma arundinaceum tri10 in regulation of terpene biosynthetic genes and in control of metabolic flux. Applied and Environmental Microbiology. 122:31-46. https://doi.org/10.1016/j.fgb.2018.11.001.
Kim, H.-S., Proctor, R., Busman, M., Brown, D.W. 2018. Genomics and evolution of fungal gene clusters responsible for synthesis of sphinganine-analog metabolites of concern to human health and food safety. [abstract].
-(Peer Reviewed Journal)
Lindo, L., McCormick, S.P., Cardoza, R.E., Brown, D.W., Kim, H.-S., Alexander, N.J., Proctor, R.H., Gutierrez, S. 2018. Effect of deletion of a trichothecene toxin regulatory gene on the secondary metabolism transcriptome of the saprophytic fungus Trichoderma arundinaceum. Fungal Genetics and Biology. 119:29-46. https://doi.org/10.1016/j.fgb.2018.08.002.
-(Peer Reviewed Journal)
Zhou, X., O'Donnell, K., Kim, H.-Y., Proctor, R.H., Doehring, G., Cao, Z.-M. 2018. Heterothallic sexual reproduction in three canker-inducing tree pathogens within the Fusarium torreyae species complex. Mycologia. 110(4):710. https://doi.org/10.1080/00275514.2018.1491766.
Cardoza, R.E., Proctor, R., McCormick, S.P., Kim, H.-S., Stanley, A.M., Lindo, L., Kelly, A.C., Brown, D.W., Vaughan, M.M., Alexander, N.J., Busman, M., Santiago, G. 2018. New insights into the organization and regulation of trichothecene biosynthetic genes in Trichoderma [abstract].
Proctor, R., Kim, H., Villani, A., Hao, G., Bakker, M.G., Brown, D.W., Vaughan, M.M., Busman, M., O'Donnell, K., Moretti, A., Susca, A., Ward, T.J., Gutierrez, S., McCormick, S.P. 2018. Distribution and evolution of genes responsible for biosynthesis of mycotoxins in Fusarium. Meeting Abstract [abstract].
Brown, D.W., Villani, A., Susca, A., Moretti, A., Proctor, R., McCormick, S.P., Kim, H. 2018. Novel Zn(II)2Cys6 transcription factor in Fusarium equiseti trichothecene gene cluster is a pathway specific and global regulator [abstract].
-(Peer Reviewed Journal)
Proctor, R.H., McCormick, S.P., Kim, H.-S., Cardoza, R.E., Stanley, A.M., Lindo, L., Kelly, A., Brown, D.W., Lee, T., Vaughan, M.M., Alexander, N.J., Busman, M., Gutierrez, S. 2018. Evolution of structural diversity of trichothecenes, a family of toxins produced by plant pathogenic and entomopathogenic fungi. PLoS Pathogens. 14(4): e1006946. https://doi.org/10.1371/journal.ppat.1006946.
-(Review Article)
Bakker, M.G., Brown, D.W., Kelly, A.C., Kim, H.-S., Kurtzman, C.P., McCormick, S.P., O'Donnell, K.L., Proctor, R.H., Vaughan, M.M., Ward, T.J. 2018. Fusarium mycotoxins: a trans-disciplinary overview. Canadian Journal of Plant Pathology. 40(2):161-171. https://doi.org/10.1080/07060661.2018.1433720.
-(Peer Reviewed Journal)
Laraba, I., Boureghda, H., Abdallah, N., Bouaicha, O., Obanor, F., Moretti, A., Geiser, D.M., Kim, H.-S., McCormick, S.P., Proctor, R.H., Kelly, A.C., Ward, T.J., O'Donnell, K. 2017. Population genetic structure and mycotoxin potential of the wheat crown rot and head blight pathogen Fusarium culmorum in Algeria. Fungal Genetics and Biology. 103:34-41.