Brian W. Brunelle
National Animal Disease Center
Phone (515) 337-7612
P.O. Box 70
1920 Dayton Ave.
Ames, IA 50010
B.S. Rensselaer Polytechnic Institute, Biochemistry and Biophysics, 1997
Ph.D. University of California, Berkeley, Infectious Diseases and Immunity, 2005
Postdoctoral Researcher, National Animal Disease Center, Virus and Prions Unit, 2008
My research objectives are to identify factors that influence Salmonella Typhimurium virulence (invasion, colonization, and shedding), with an emphasis on the impact antibiotics have on multidrug-resistant (MDR) isolates.
With my collaborators, I have:
•• Discovered particular antibiotics commonly used in livestock can induce the invasiveness of MDR Salmonella.
•• Identified antibiotics that can promote attachment and decrease flagella in MDR Salmonella.
••Determined antibiotic exposure to MDR Salmonella can stimulate phage-mediated horizontal gene transfer to naive bacteria.
Briony Atkinson, Biological Science Laboratory Technician
Devin Holman, Postdoctoral Researcher
Recent Publications: Complete list of published work:
1. Brunelle BW, Bearson BL, Bearson SMD (2015). Chloramphenicol and tetracycline decrease motility and increase invasion and attachment gene expression in multidrug-resistant Salmonella enterica serovar Typhimurium. Front Microbiol 5:801.
2. Bearson BL, Brunelle BW (2015). Fluoroquinolone induction of phage-mediated gene transfer in multidrug-resistant Salmonella. Int J Antimicrob Agents 46: 201-204.
3. Lippolis JD, Brunelle BW, Reinhardt TA, Sacco RE, Nonnecke BJ, Dogan B, Simpson K, and Schukken Y (2014). Proteomic analysis reveals protein expression differences in Escherichia coli strains associated with persistent versus transient mastitis. J Proteomics 108: 373-381.
4. Bearson BL, Allen HK, Brunelle BW, Lee I, Casjens SR, Stanton TB (2014). The agricultural antibiotic carbadox induces phage-mediated gene transfer in Salmonella. Front Microbiol 5: 52.
5. Brunelle BW, Bearson SMD, Bearson BL (2013). Tetracycline accelerates the temporally-regulated invasion response in specific isolates of multidrug-resistant Salmonella enterica serovar Typhimurium. BMC Microbiology 13: 202.