Alternatives to Antibiotics (ATA)

Challenges and Solutions in Animal Production

OIE Headquarters, Paris, France

December 12-15, 2016

Opening Ceremony


• Program Review - Objectives and Expected Outcomes
  Cyril G. Gay

• Keynote Presentation: New approaches to address antimicrobial resistance in animals
  Harald Brussow

Session 1
Vaccines

• Prioritization of diseases for which vaccines could reduceantimicrobial use in animals
  Elisabeth Erlacher-Vindel

• Challenges and solutions for improved intestinal vaccinations
  Eric Cox

• Heat stable Bacillus Spores as Vaccines
  Simon L. Cutting

• Benefits of a Herpesvirus of Turkey vector vaccine for InfectiousBursal Disease (HVT-IBD) in control of immuno-depression inbroiler chickens and decrease of use of antibiotic medication
  Stéphane Lemiere

• Recombinant orally effective vaccine platforms expressingputative conserved antigens for reduced antimicrobial usage inpoultry
  Lisa R. Bielke

• Opportunities and problems in vaccination against opportunisticpathogens: The example of Clostridium perfringens in calves and chickens
  Evy Goossens

• Pasteurellaceae oral vaccine vector for economically importantdiseases of cattle
  Robert Briggs

• Reduction of antibiotic treatments in broilers by the use of a liveCoccidiosis vaccine in rotation with anticoccidial feed
  Jesus Rubio



 

Session 2
Microbial-derived products

• Exploiting CRISPR-Cas nucleases to produce sequence-specificantimicrobials
  David Bikard

• Probiotic product development with fecal microbiome transplantsas alternatives to antibiotics in broiler chickens
  Brian Oakley

• Novel antimicrobial compounds from microbial sources
  Joseph O. Rich

• Bacteriocins as alternatives to antibiotics: the case of enterocinsDD14 and DD28
  Djamel Drider

• Artilysins - Novel antibacterial tools for industrial animal proteinproduction
  Stefan Miller

• Microbial-ecology guided discovery of antibiofilm compoundsfrom marine sponges
  Jason Kwan



 

Session 3
Phytochemicals

• Dietary phytonutrients as alternatives-to-antibiotics in agriculturalanimals: Mode of action in modulating cross-talks amongimmunity, disease resistance and gut microbiota
  Hyun Lillehoj

• Dietary phytonutrients enhance disease resistance in swine
  Yanhong Liu

• Phytonutrients as alternative feeding strategy to improve performance of cattle without using an antibiotic
  Sergio Calsamiglia

• Impact of dietary tannins on rumen microbiota in bovine
  Mariano E. Fernández Miyakawa

• Meta-analysis of broiler research shows that VariumTM results infeed efficiency equal to antibiotics
  Fang Chi



 

Session 4
Immune-related products

• Innate defense mechanisms and passive immunity
  Peter M. Heegaard

• Immunomodulators derived from host defense peptides
  Albert van Dijk

• Egg shell membrane improves immunity of post hatch poultry: aparadigm for nutritional immunomodulation
  Narayan C. Rath

  Green algal sulfated polysaccharides: a natural alternative toantibiotics via modulation of the intestinal immune response
  Mustapha Berri

• Maintenance of vascular integrity via ARF6-GTP inhibitionprotects mice from MDR Acinetobacter infection
  Ashraf S. Ibrahim

• Swine plasma immunoglobulins for prevention and treatment ofpost-weaning diarrhea
  Chris Juul Hedegaard



 

Session 5
Innovative Drugs, Chemicals, and Enzymes

• Non-resistance-inducing antibacterial polymers andnanomedicines
  Song Liu

• Bacterial anti-virulence strategy as an alternative to antibiotics
  Damien Maura

• Cationic amphiphilic non-hemolytic synthetic polymers aspotential agents to combat bacteria with antibiotics resistance
  Nanloh Yang

• Reducing antimicrobial dependence through feed additives thatbolster immune readiness, disease resistance, and productionperformance in farmed fish
  Benjamin Beck

• Development of technique to circularly produce enzyme,probiotics and oligosaccharide, and solutions to replaceantibiotics in a low-cost way
  Nicole Zhou



 

Session 6
Regulatory Pathways to Enable the Licensing of Alternatives to Antibiotics and Issues and Opportunities from Funders’ Perspective

• EU approach to authorization of novel technologies withparticular emphasis on alternatives to antibiotics
  Faye Ioannou

• FDA’s innovation initiative to evaluate novel emergingtechnologies and international cooperation in the area ofinnovation
  Cindy Burnsteel

• Regulation on the use of antibiotics and authorization of herbalmedicines in China
  Shixin Xu

• Do innovative solutionsrequire novel regulatory paradigms?
  Patricia Logie

  The sequence of success: antibiotic alternative development fromthe startup perspective
  Lucia Mokres

Organized by USDA with the support of the OIE