|Porter, JR., Robert - PURDUE UNIV - IN|
|Stone, Henry - US DEPT OF AGRI - RETIRED|
Submitted to: Journal Of Poultry Science
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: July 1, 1999
Publication Date: N/A
Interpretive Summary: The immune system of the newly hatched chick lacks the ability to fully respond to infections. The current study examined just how well the serum and intestinal immune system in these young birds could respond to an infection by Salmonella enteritidis (SE). We found that challenging birds at this young age results in a long term persistent infection which severely inhibits their immunity - only half of the birds produces detectable antibodies at any one time. This poor response to the infection lasted at least 23 weeks and was observed in both the serum and intestine. Responsiveness to vaccination with inactivated SE or Newcastle disease virus was also reduced which could have serious implications for vaccination regimens currently in place in the field. These results indicate that infection of birds with SE in the hatchery could result in serious problems for the flock and reveal the importance of minimizing the exposure of chicks to SE at this very susceptible period.