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United States Department of Agriculture

Agricultural Research Service

Title: The Preventive Role of Vitamins in Pre-Cancerous Stomach Lesions

Authors
item Yeum, Kyung-Jin - HNRCA-TUFTS
item Paiva, Sergio - HNRCA-TUFTS
item Zhu, Shunshi - SHANGHAI 2ND MED UNIV
item Xiao, Shudong - SHANGHAI 2ND MED UNIV
item Mason, Joel - HNRCA-TUFTS
item Russell, Robert - HNRCA-TUFTS

Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: June 1, 1998
Publication Date: June 1, 1998
Citation: YEUM, K., PAIVA, S.A., ZHU, S., XIAO, S., MASON, J., RUSSELL, R.M. THE PREVENTIVE ROLE OF VITAMINS IN PRE-CANCEROUS STOMACH LESIONS. MEETING ABSTRACT. 1998.

Technical Abstract: A prospective intervention trial was conducted to determine whether supplementation of a mixture of 9-cis and all-trans b-carotene (ATBC), or ATBC alone or folic acid would affect the course of premalignant alterations in the gastric mucosa. Dyspeptic patients seen at the Shanghai Medical Institute and several surrounding hospitals who were over the age of 18 and who were noted, on endoscopy, to have a lesion consistent with chronic atrophic gastritis, gastric dysplasia or intestinal metaplasia initially were chosen for study. The subjects (n=162) who were willing to participate in the prospective study were randomized to receive either placebo (n=42), 20 mg of folate (n=33), 30 mg natural b-carotene (n=44, a mixture of 51 % of ATBC and 34 % of 9-cis b-carotene) or 30 mg synthetic b-carotene (n=43, 95 % of ATBC) each day for 1yr. Carotenoids, retinol, and tocopherols in the plasma were assayed by reverse-phase HPLC. Plasma folate was measured by a standard microbiologic microtiter plate assay. Baseline levels of plasma carotenoids (lutein/zeaxanthin, a- & b-cryptoxanthin, a-carotene, ATBC, and 13-cis b-carotene), retinol, tocopherol (g - & a- tocopherols) and folic acid showed no statistical differences among the four groups. After supplementation of natural b-carotene, the plasma a-carotene, all- trans- & 13-cis-b-carotene were significantly increased as compared to baseline. Similarly, the plasma concentration of ATBC and 13-cis b- carotene were significantly increased at 1 year in the group supplemented with synthetic b-carotene. These plasma data show that the compliance of the subjects in this intervention trial was successful.

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