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Title: MYOSTATIN MUTATIONS CAUSE DOUBLE MUSCLING IN CATTLE

Authors
item Smith, Timothy
item Kambadur, Ravi - AGRESEARCH, NEW ZEALAND
item Sharma, Mridula - AGRESEARCH, NEW ZEALAND
item Sonstegard, Tad
item Lopez, Nestor
item Kappes, Steven
item Casas, Eduardo
item Stone, Roger
item Keele, John
item Fahrenkrug, Scott

Submitted to: Meeting Abstract
Publication Type: Proceedings
Publication Acceptance Date: October 27, 1997
Publication Date: N/A

Technical Abstract: A partially recessive locus (mh) causes a heritable syndrome of generalized muscular hypertrophy in cattle, a result of cellular hyperplasia. The mh locus is mapped to an interval on bovine chromosome 2 (BTA2) between the COL3A1 and PROC genes in both Belgian Blue and Piedmontese breeds, suggesting the same locus is responsible in this breed. We show that myostatin, a member of the TGF-beta gene family, maps to the same interval, making it a positional candidate gene for mh. RT-PCR analysis shows that myostatin is present at approximately normal levels at the RNA level in Belgian Blue embryos. However, mutation analysis shows that each breed has a distinct mutation in the coding portion of the cDNA that is predicted to interfere with the function of the gene.

   
 
 
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