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United States Department of Agriculture

Agricultural Research Service

Title: Natural Products As Leads for New Herbicide Modes of Action

Authors
item DUKE, STEPHEN
item DAYAN, FRANCK
item Hernandez, A - BASQUE GOVT EDU,SPAIN
item DUKE, MARY
item ABBAS, HAMED

Submitted to: Brighton Conference Symposium Proceedings
Publication Type: Proceedings
Publication Acceptance Date: November 17, 1997
Publication Date: N/A

Interpretive Summary: A major objective of the discovery effort of the herbicide industry is to find new molecular target sites. One strategy for discovery of new molecular targets is to determine those for naturally-occurring phytotoxins. The relatively few molecular targets of natural projects that are known are almost all different from those of commercial herbicides. We describe the novel sites of action and novel mechanisms of action of some of the compounds with which we have worked. These include AAL-toxin, artemisinin, australifungin, cornexistin, 1,8-cineole, cyperin, and hydantocidin. Each of these compounds appears to have a mechanism of action that is very different from that of any commercial herbicide.

Technical Abstract: A major objective of the discovery effort of the herbicide industry is to find new molecular target sites. One strategy for discovery of new molecular targets is to determine those for naturally-occurring phytotoxins. The relatively few molecular targets of natural projects that are known are almost all different from those of commercial herbicides. We describe the novel sites of action and novel mechanisms of action of some of the compounds with which we have worked. These include AAL-toxin, artemisinin, australifungin, cornexistin, 1,8-cineole, cyperin, and hydantocidin. Each of these compounds appears to have a mechanism of action that is very different from that of any commercial herbicide.

Last Modified: 9/29/2014
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