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ARS Home » Pacific West Area » Davis, California » Western Human Nutrition Research Center » Obesity and Metabolism Research » Research » Publications at this Location » Publication #326915
Title: Perinatal triphenyl phosphate exposure accelerates type 2 diabetesonset and increases adipose accumulation in UCD-type 2 diabetesmellitus rats

Author
item GREEN, ADRIAN - University Of California
item GRAHAM, JAMES - University Of California
item GONZALEZ, EDUARDO - University Of California
item LAFRANO, MICHAEL - University Of California
item HE, GUOCHUN - University Of California
item PERTOPOULOU, SYRAGO-STYLIANI - California Environmental Protection Agency
item PARK, JUNE-SOO - California Environmental Protection Agency
item DENISON, MICHAEL - University Of California
item Newman, John

Submitted to: Reproductive Toxicology
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 7/12/2016
Publication Date: 7/12/2016
Citation: Green, A.J., Graham, J.L., Gonzalez, E.A., Lafrano, M.R., He, G., Pertopoulou, S.E., Park, J., Denison, M., Newman, J.W. 2016. Perinatal exposure to the flame retardant triphenyl phosphate accelerates the onset of type 2 diabetes and causes adipose accumulation in UCD-type 2 diabetes mellitus rats. Reproductive Toxicology. pii: S0890-6238(16)30266-0. doi: 10.1016/j.reprotox.2016.07.009.

Interpretive Summary: Triphenyl phosphate (TPP) is an additive used globally to in furniture, foams, and electronics products either as a flame retardant or plasticizer and is found in household dust. Reportedly, exposing mice to a flame retardant that contained this compound from mid-gestation to weaning caused obesity and changes in glucose intolerance, hallmarks of type 2 diabetes mellitus (T2DM). In this study, we administered a low dose of TPP to UC Davis type 2 diabetes mellitus-prone (UCD-T2DM) rats from gestational day 8.5 to weaning and evaluated metabolic phenotypes of 3.5 month old male and female rats and male rats up to 6 months to assess the development of obesity and type 2 diabetes mellitus (T2DM), respectively. Perinatal TPP exposure increased body and fat weight in 3.5 month old male and female rats, while leptin and cumulative energy intake were elevated in males and females, respectively. Male rats with perinatal TPP exposure had an accelerated onset of T2DM and had changes in non-esterified fatty acid profiles consistent with changes in lipid metabolism previously reported with diabetes. Together, these observations suggest that perinatal exposure to TPP causes obesity in male and female UCD-T2DM rats and accelerates T2DM onset in male UCD-T2DM rats.

Technical Abstract: Triphenyl phosphate (TPP) is an additive used globally to in furniture, foams, and electronics products either as a flame retardant or plasticizer and is found in household dust. We administered TPP from gestational day 8.5 to weaning and evaluated metabolic phenotypes of 3.5 month old male and female rats and male rats up to 6 months to assess the development of obesity and type 2 diabetes mellitus (T2DM), respectively. Perinatal TPP exposure increased body and fat weight in 3.5 month old male and female rats, while leptin and cumulative energy intake were elevated in males and females, respectively. Male rats with perinatal TPP exposure had an accelerated onset of T2DM and had increased total saturated-, total mono-unsaturated- and total non-esterified- fasting fatty acids, including total saturated and monounsaturated fatty acids. These observations suggest that perinatal exposure to TPP causes obesity in male and female UCD-T2DM rats and accelerates T2DM onset in male UCD-T2DM rats.