Skip to main content
ARS Home » Midwest Area » Ames, Iowa » National Animal Disease Center » Food Safety and Enteric Pathogens Research » Research » Publications at this Location » Publication #322687
Title: Antibiotic exposure can induce various bacterial virulence phenotypes in multidrug-resistant Salmonella enterica serovar Typhimurium

Author
item Brunelle, Brian
item Bearson, Bradley - Brad
item Bearson, Shawn

Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 10/19/2015
Publication Date: 10/27/2015
Citation: Brunelle, B.W., Bearson, B.L., Bearson, S.M. 2015. Antibiotic exposure can induce various bacterial virulence phenotypes in multidrug-resistant Salmonella enterica serovar Typhimurium [abstract]. In: Proceedings of 14th Annual Great Plains Infectious Disease Meeting, November 6-7, 2015, Lawrence, Kansas. p. 38.

Interpretive Summary:

Technical Abstract: Salmonella is one of the most prevalent bacterial foodborne diseases in the United States and causes an estimated 1 million human cases every year. Multidrug-resistant (MDR) Salmonella has emerged as a public health issue as it has been associated with increased morbidity in humans and mortality in livestock compared to antibiotic sensitive isolates. It is known that antibiotics can have unintended consequences on bacteria, and the goal of my research has been to characterize some of these collateral effects in MDR Salmonella Typhimurium. We have found that various antibiotics can enhance a variety of virulence phenotypes in MDR S. Typhimurium, such as inducing cellular invasion, increasing antibiotic resistance, and stimulating horizontal gene transfer. These factors may underlie some of the clinical observations associated with MDR Salmonella virulence.