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ARS Home » Northeast Area » Beltsville, Maryland (BARC) » Beltsville Agricultural Research Center » Animal Biosciences & Biotechnology Laboratory » Research » Publications at this Location » Publication #309752
Title: Phage lytic proteins: biotechnological applications beyond clinical antimicrobials

Author
item RODRIGUEZ-RUBIO,, LORENA - Institute Of Dairy Products Of Asturias (IPLA-CSIC)
item GUTIERREZ, DIANE - Institute Of Dairy Products Of Asturias (IPLA-CSIC)
item Donovan, David
item MARTINEZ, BEATRIZ - Institute Of Dairy Products Of Asturias (IPLA-CSIC)
item RODRIGUEZ, ANA - Institute Of Dairy Products Of Asturias (IPLA-CSIC)
item GARCIA, PILAR - Institute Of Dairy Products Of Asturias (IPLA-CSIC)

Submitted to: Chemical Rubber Company Critical Reviews in Biotechnology
Publication Type: Review Article
Publication Acceptance Date: 11/1/2014
Publication Date: 1/21/2015
Citation: Rodriguez-Rubio,, L., Gutierrez, D., Donovan, D.M., Martinez, B., Rodriguez, A., Garcia, P. 2015. Phage lytic proteins: biotechnological applications beyond clinical antimicrobials. Chemical Rubber Company Critical Reviews in Biotechnology. DOI:10.3109/07388551.2014.993587.

Interpretive Summary:

Technical Abstract: Most bacteriophages encode two types of cell wall lytic proteins: Endolysins (lysins) and virion-associated peptidoglycan hydrolases. Both enzymes have the ability to degrade the peptidoglycan of Gram positive bacteria resulting in cell lysis when they are applied externally. Bacteriophage lytic proteins have a demonstrated potential in treating animal models of infectious diseases. There has also been an increase in the study of these lytic proteins for their application in areas such as food safety, pathogen detection/diagnosis, surfaces disinfection, vaccine development and nanotechnology. This review summarizes the more recent developments, outlines the full potential of these proteins to develop new biotechnological tools and discusses the feasibility of these proposals.