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United States Department of Agriculture

Agricultural Research Service

Research Project: Intervention Strategies to Control and Prevent Enteric Viral Diseases of Poultry

Location: Endemic Poultry Viral Diseases Research Unit

Title: Immunoresponse induced by newcastle disease virus (NDV) vaccine vectors in commercial chicks with the presence of NDV maternal antibody

item Zhao, Wei -
item Zhang, Zhenyu -
item Wen, Guoyuan -

Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: March 3, 2014
Publication Date: N/A

Technical Abstract: To address the concern that Newcastle disease virus (NDV) maternal antibody (Mab) in chicks may suppress the immunoresponse to the NDV vectored vaccines, we evaluated the replication and immunogenicity of the LaSota and PHY LMV42 strain-based vectors in chickens which had naturally acquired NDV maternal antibody. The results showed that both LaSota and PHY LMV42 strain vectors could replicate in commercial Leghorn chickens with a mean Mab HI titer of 6.4 (Log2) when inoculated at age of day 3, and induce antibody response after two weeks of vaccination as indicated by mean HI titers which were significantly higher than the declining Mab titers in the non-vaccinated control birds. The results suggested that the LaSota and PHY LMV42 vaccine strains can be used as live vaccine vectors in chicks in the presence of NDV Mab to deliver a foreign antigen as dual or multivalent vaccines.

Last Modified: 9/10/2014
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