|Davis, Teresa -|
Submitted to: Book Chapter
Publication Type: Book / Chapter
Publication Acceptance Date: October 18, 2012
Publication Date: May 7, 2013
Citation: Burrin, D.G., Davis, T.A. 2013. Mechanism of nutrient sensing. In: Ross, A.C., Caballero, B., Cousins, R.J., Tucker, K.L., Ziegler, T.R., editors. Modern Nutrition in Health and Disease, 11th edition, Part II. Nutritional roles in integrated biologic systems, Section B. Digestive, endocrine, immune, and neural mechanisms, Chapter 47. Philadelphia, PA:Wolters Kluwar-Lippincott, Williams & Wilkins Publishers. p. 626-632. Technical Abstract: The term nutrient sensing has emerged to describe the molecular mechanisms by which nutrients and their metabolites interact with various cell surface receptors, intracellular signaling proteins, and nuclear receptors, and modulate the activity of a complex network of signaling pathways that regulate the growth and function of cells. Nutrients also trigger the release of hormones and neurotransmitters that act on neighboring or distant cells through paracrine or endocrine mechanisms to regulate cellular growth and function. This chapter discusses some of the key nutrient sensing mechanisms in different tissues within the body.