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Title: Searching for the noninvasive biomarker Holy Grail: Are urine proteomics the answer?

Author
item VOSS, JOACHIM - University Of Washington
item GOO, YOUNG - University Of Washington
item CAIN, KEVIN - University Of Washington
item WOODS, NANCY - University Of Washington
item JARRETT, MONICA - University Of Washington
item SMITH, LYNNE - University Of Washington
item SHULMAN, ROBERT - Children'S Nutrition Research Center (CNRC)
item HEITKEMPER, MARGARET - University Of Washington

Submitted to: Biological Research for Nursing
Publication Type: Review Article
Publication Acceptance Date: 5/1/2011
Publication Date: 7/1/2011
Citation: Voss, J., Goo, Y.A., Cain, K., Woods, N., Jarrett, M., Smith, L., Shulman, R., Heitkemper, M. 2011. Searching for the noninvasive biomarker Holy Grail: Are urine proteomics the answer? Biological Research for Nursing. 13(3):235-242.

Interpretive Summary:

Technical Abstract: Recently, biobehavioral nursing scientists have focused their attention on the search for biomarkers or biological signatures to identify patients at risk for various health problems and poor disease outcomes. In response to the national impetus for biomarker discovery, the measurement of biological fluids and tissues has become increasingly sophisticated. Urine proteomics, in particular, may hold great promise for biobehavioral-focused nursing scientists for examination of symptom- and syndrome-related research questions. Urine proteins are easily accessible secreted proteins that provide direct and indirect windows into bodily functions. Advances in proteomics and biomarker discovery provide new opportunities to conduct research studies with banked and fresh urine to benefit diagnosis, prognosis, and evaluation of outcomes in various disease populations. This article provides a review of proteomics and a rationale for utilizing urine proteomics in biobehavioral research. It addresses, as well, some of the challenges involved in data collection and sample preparation.