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United States Department of Agriculture

Agricultural Research Service

Research Project: GENETIC AND BIOLOGICAL DETERMINANTS OF AVIAN TUMOR VIRUS PATHOGENICITY, TRANSMISSION, AND EVOLUTION

Location: Avian Disease and Oncology Laboratory

Title: Spontaenous Avian Leukosis Virus-like lymphomas in specific-pathogen-free chickens inoculated with serotype 2 Marek’s disease virus

Authors
item Fadly, Aly
item Cao, Weisheng -
item Fulton, Richard -
item Mays, Jody

Submitted to: American Association of Avian Pathologists
Publication Type: Abstract Only
Publication Acceptance Date: July 21, 2013
Publication Date: July 21, 2013
Citation: Fadly, A.M., Cao, W., Fulton, R.M., Mays, J.K. 2013. Spontaenous Avian Leukosis Virus-like lymphomas in specific-pathogen-free chickens inoculated with serotype 2 Marek’s disease virus [abstract]. American Association of Avian Pathologists, July 19-23, 2013, Chicago, Illinois. p. 31.

Technical Abstract: Chickens of Avian Disease and Oncology Laboratory (ADOL) line alv6, known to develop spontaneous avian leukosis virus (ALV)-like lymphomas at two years of age or older, were inoculated either in-ovo, or at 1 day of age with strain SB-1 of serotype 2 Marek’s disease virus (MDV). Inoculated and uninoculated control chickens were monitored for development of spontaneous ALV-like lymphomas within 48-50 weeks of age. The data indicate that by 50 weeks of age, the incidence of spontaneous ALV-like lymphomas ranged from 4.5% to 7% in chickens inoculated with strain SB-1 of MDV in-ovo, and 10.5 % in chickens inoculated with virus at hatch, compared with 0% in uninoculated control chickens. Strategies to eliminate or reduce incidence of such spontaneous lymphomas will be discussed.

Last Modified: 12/25/2014
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