Title: Epigenomic landscape modified by histone modification correlated with activation of IGF2 gene Authors
Submitted to: BARC Poster Day
Publication Type: Abstract Only
Publication Acceptance Date: September 24, 2013
Publication Date: October 1, 2013
Citation: Carter, O.L., Li, R.W., Li, C. 2013. Epigenomic landscape modified by histone modification correlated with activation of IGF2 gene. BARC Poster Day. 1:10. Technical Abstract: The links of histone post-translational modifications and chromatin structure to cell cycle progression, DNA replication, and overall chromosome functions are very clear. The modulation of genome expression as a consequence of chromatin structural changes is most likely a basic mechanism. The epigenomic landscape can be modified by short-chain fatty acid-induced histone modification, thereby regulating genomic activities, especially gene expression. The goal of this experiment was to define the interaction of the transcriptional machinery within the epigenomic landscape. To illustrate the fundamental association of the chromatin modification that may play a role in the activation of the IGF2 gene, a high-resolution map of the major chromatin modification at the IGF2/H19 locus was constructed by mining existing RNA-seq and ChIP-seq data. The results revealed that there is a strong correlation between the activation of the IGF2 gene and histone modifications, indicating that IGF2 gene activity may be regulated by a dispersed epigenomic landscape.