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United States Department of Agriculture

Agricultural Research Service

Research Project: DIETARY MODULATION OF OBESITY-RELATED CANCER BY SELENIUM Title: Plasma and breastmilk selenium in HIV-infected Malawian mothers is positively associated with infant selenium status at 2 or 6 and 24 weeks post-partum but is not associated with supplementation

Authors
item Flax, V -
item Bentley, M -
item Combs, Gerald
item Chasela, C -
item Kayira, D -
item Tegha, G -
item Daza, E -
item Jamieson, D -
item Van Der Horst, C -
item Adair, L -

Submitted to: Federation of American Societies for Experimental Biology Conference
Publication Type: Abstract Only
Publication Acceptance Date: October 27, 2012
Publication Date: April 9, 2013
Citation: Flax, V.L., Bentley, M.E., Combs, G.F., Chasela, C.S., Kayira, D., Tegha, G., Daza, E.J., Jamieson, D.J., Van Der Horst, C.M., Adair, L.S. 2013. Plasma and breastmilk selenium in HIV-infected Malawian mothers is positively associated with infant selenium status at 2 or 6 and 24 weeks post-partum but is not associated with supplementation. Federation of American Societies for Experimental Biology Conference. 27:845.16.

Technical Abstract: Selenium (Se) levels are typically low in HIV-infected individuals, but have been increased by supplementation in previous studies. In HIV-infected populations, the effect of Se supplementation on breastmilk Se and, consequently, plasma Se levels in exclusively breastfed infants is unknown. HIV-infected Malawian mothers in the Breastfeeding, Antiretrovirals, and Nutrition study were randomized to receive a daily nutritional supplement containing 1 RDA of Se from 0-24 wks post-partum or no supplement. In a sub-sample of 514 mothers and their uninfected infants, we used regression models to examine the effects of the supplement on maternal plasma and breastmilk Se and the association between the Se concentration in breastmilk and infant plasma at either 2 or 6 weeks and 24 weeks. Supplementation was not associated with maternal plasma or breastmilk Se at any time point. Mean maternal (81.1- 86.1 ng/mL) and infant (55.6- 61.0 ng/mL) plasma Se increased, while breastmilk (14.4- 9.8 ng/mL) levels declined from 2 or 6 to 24 wks. Higher breastmilk Se was associated with higher infant plasma Se at 2 or 6 and 24 weeks (p<0.001). Similar patterns of change in Se levels in breastmilk and maternal and infant plasma have been documented and are probably physiological. The lack of effect of Se supplementation may be related to the low dose (75 µg/d) compared to other trials.

Last Modified: 11/25/2014
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