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United States Department of Agriculture

Agricultural Research Service

Research Project: Functional Genomics Approaches for Controlling Diseases of Poultry

Location: Animal Biosciences and Biotechnology Laboratory

Title: Approaches to improve poultry vaccination using novel poultry adjuvants against coccidiosis

Author
item Lillehoj, Hyun

Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: September 24, 2012
Publication Date: October 15, 2012
Citation: Lillehoj, H. S. 2012. Approaches to improve poultry vaccination using novel poultry adjuvants against coccidiosis. "Recent Update on Poultry Vaccination", Dubai, UAE.

Technical Abstract: In this review, various new approaches to improve poultry adaptive immunity against coccidiosis through vaccination will be addressed using the recently published data. To improve poultry production and to meet the demands for the ever-increasing world human population, we need to develop new strategies to enhance gut adaptive immunity. For example, we are interested to effectively elicit protective immunity using simple proteins of enteric pathogens. In past several years, we have successfully demonstrated that commercially available mineral oil-in-water adjuvants elicited effective host immune response to coccidia protein antigens when protein antigens were emulsified in this adjuvant. The commercial Montanideâ„¢ ISA 71 VG adjuvants elicited serum antibodies against clostridium proteins that were used as immunogens and induced partial protective immune response when vaccinated birds were challenged with live coccidia parasites. Based on immunological parameters that were evaluated in this study, this commercial ISA 71 VG mineral oil-in-water adjuvant showed immune enhancing effect in broiler chickens. These results suggest that various strategies can be employed to enhance the efficacy of poultry vaccination.

Last Modified: 10/1/2014
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