Submitted to: Toxicologist
Publication Type: Abstract Only
Publication Acceptance Date: January 1, 2012
Publication Date: March 11, 2012
Citation: Riley, R.T. 2012. Ceramide, sphingoid bases, and sphingoid base metabolites as lipid mediators in signaling pathways leading to cell death and disease [abstract]. The Toxicologist (supplement to Toxicological Sciences). 126(1):178. Interpretive Summary: Abstract - no summary required.
Technical Abstract: Increased ceramide generation de novo is known to be involved in the mechanism of action of many chemotherapeutic agents and conditions which disrupt cell cycle progression and induce cell death. Conversely, the metabolism of ceramide to sphingoid bases and and sphingoid base 1-phosphates has been implicated in cell survival and inhibition of cell death. Complicating this picture is the fact that fungal toxins that inhibit ceramide biosynthesis and induce elevated levels of sphingoid base 1-phosphates also induce increased cell death and cancer in animal models. In addition, elevated levels of sphingoid base 1-phosphates may disrupt signaling via disruption of sphingosine 1-phosphate receptor (S1PR1-5) signaling. This presentation will provide an overview of sphingolipids as mediators of regulatory processes involved in cell growth, differentiation, cell migration, vascular regulation, and cell death.