Page Banner

United States Department of Agriculture

Agricultural Research Service

Research Project: NUTRITION, OBESITY, CARDIOVASCULAR HEALTH AND GENOMICS

Location: Human Nutrition Research Center on Aging

Title: Chronobiological aspects of obesity and metabolic syndrome

Authors
item Gomez-Abellan, Purificacion -
item Madrid, Juan Antonio -
item Ordovas, Jose -
item Garaulet, Marta -

Submitted to: Endocrinology and Nutrition
Publication Type: Review Article
Publication Acceptance Date: August 4, 2011
Publication Date: January 1, 2012
Citation: Gomez-Abellan, P., Madrid, J., Ordovas, J.M., Garaulet, M. 2012. Chronobiological aspects of obesity and metabolic syndrome. Endocrinology and Nutrition. 59(1):50-61.

Technical Abstract: Circadian rhythms (approximately 24h) are widely characterized at molecular level and their generation is acknowledged to originate from oscillations in expression of several clock genes and from regulation of their protein products. While general entrainment of organisms to environmental light-dark cycles is mainly achieved through the master clock of the suprachiasmatic nucleus in mammals, this molecular clockwork is functional in several organs and tissues. Some studies have suggested that disruption of the circadian system (chronodisruption (CD)) may be causal for manifestations of the metabolic syndrome. This review summarizes (1) how molecular clocks coordinate metabolism and their specific role in the adipocyte; (2) the genetic aspects of and scientific evidence for obesity as a chronobiological illness; and (3) CD and its causes and pathological consequences. Finally, ideas about use of chronobiology for the treatment of obesity are discussed.

Last Modified: 9/23/2014
Footer Content Back to Top of Page