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United States Department of Agriculture

Agricultural Research Service

Research Project: IMPACT OF EARLY DIETARY FACTORS ON CHILD DEVELOPMENT AND HEALTH

Location: Arkansas Children's Nutrition Center

Title: Flavonoid intake and bone health

Authors
item Weaver, Connie -
item Alekel, D -
item Ward, Wendy -
item Ronis, Martin -

Submitted to: Journal of Nutrition in Gerontology and Geriatrics
Publication Type: Review Article
Publication Acceptance Date: July 13, 2012
Publication Date: August 14, 2012
Citation: Weaver, C.M., Alekel, D.L., Ward, W.E., Ronis, M.J. 2012. Flavonoid intake and bone health. Journal of Nutrition in Gerontology and Geriatrics. 31(3):239-253.

Technical Abstract: Flavonoids, found in a wide diversity of plant foods, from fruits and vegetables, herbs and spices, essential oils, and beverages, have the most potential of dietary components for promotion of bone health beyond calcium and vitamin D. Recent epidemiological studies show flavonoid consumption to have a stronger association with bone than general fruit and vegetable consumption. Bioactive flavonoids are being assessed for properties beyond their chemical antioxidant capacity, including anti-inflammatory actions. Some have been reported to enhance bone formation and to inhibit bone resorption through their action on cell signaling pathways that influence osteoblast and osteoclast differentiation. Future research is needed to determine which of the flavonoids and their metabolites are most effective and at what dose, as well as the mechanism of modulationg cellular events, in order to set priorities for clinical trials.

Last Modified: 7/25/2014