Technical Abstract: Lodgepole pine is a species of great importance to the forestry industry of British Columbia. However, recent climate-change associated outbreaks of insect pests (i.e. the mountain pine beetle) and diseases (Dothistroma needle blight) have limited productivity of stands throughout its northern range. One solution is to re-plant pine plantations with seedlings from southern, warmer, and wetter origins as these might be more tolerant of insects and disease damage. This research observed that provenances from southern, warmer locales had reduced disease severities as well as increased constitutive foliar levels of secondary metabolites (phenolics and terpenoids). Since both phenolics and terpenoids are associated with host defense against pathogens, it appeared that increased levels of these compounds resulted in increased tolerance to foliar disease in lodgepole pine. Thus, the planting of lodgepole pines from southern locales to northern locations in light of climate change may ultimately reduce the impact of climate change associated disease outbreaks.