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United States Department of Agriculture

Agricultural Research Service

Research Project: FUNCTIONALIZATION OF VEGETABLE OILS FOR USE IN THE POLYMER, OLEOCHEMICAL, AND LUBRICANT INDUSTRIES

Location: Bio-oils Research Unit

Title: Study of soybean oil-based polymers for controlled release anticancer drugs

Author
item Liu, Zengshe

Submitted to: American Chemical Society National Meeting
Publication Type: Abstract Only
Publication Acceptance Date: August 19, 2012
Publication Date: August 19, 2012
Citation: Liu, Z. 2012. Study of soybean oil-based polymers for controlled release anticancer drugs [abstract]. American Chemical Society National Meeting. Cell 029. p. 84.

Technical Abstract: Soybean oil-based polymers were prepared by the ring-opening polymerization of epoxidized soybean oil with Lewis acid catalyst. The formed polymers (HPESO) could be converted into hydrogels through hydrolysis. Characterization and viscoelastic properties of this soy hydrogel and application in controlled release drugs were investigated. The HPESO hydrogels exhibited viscoelastic solid or gel behavior above 2 (wt. %) concentration at room temperature and viscous liquid behavior at 55 deg C. The thermal assembly, disassembly, and reassembly function of the HPESO hydrogel was completely reversible. The function and behavior of the HPESO hydrogel suggests that this biomaterial is suitable for application in drug delivery and scaffolds of bioengineering. Meanwhile, the HPESO hydrogels were evaluated by the loading and release of the water-soluble anticancer drug doxorubicin (Dox). The results show that this new system may offer great potential to deliver Dox effectively for the treatment of multidrug resistant breast cancer.

Last Modified: 8/29/2014