Technical Abstract: Papayas are popular in tropical and subtropical regions and are being exported in large volumes to Europe, the U.S. and Japan. The fruit has excellent taste, exotic flavor and nutritional properties, being rich in vitamins A, C, and antioxidants. However, due to its highly perishable nature it has not emerged as a major traded fruit. Papayas are susceptible to qualitative and quantitative postharvest losses. Maintenance of papaya fruit quality during the supply chain depends on orchard management, harvesting practices, packing operations, postharvest treatments, temperature management, transportation and storage conditions. Postharvest losses are attributed to mechanical damage, rapid flesh softening, decay, physiological disorders, pest infestation, and improper temperature management. The aim of postharvest technology and management in the supply chain is to provide favorable conditions to extend storage life and retain quality and nutritional attributes. This review focuses on the available research findings to retain overall papaya fruit quality and to reduce postharvest losses during the supply chain via adoption of appropriate or novel postharvest technologies.