ARS | Publication request: Interpretation and use of FRAX in clinical practice - position paper of the International Osteoporosis Foundation and the International Society for Clinical Densitometry

Submitted to: Osteoporosis International
Publication Type: Review Article
Publication Acceptance Date: June 7, 2011
Publication Date: July 21, 2011
Citation: Kanis, J., Hans, D., Cooper, C., Baim, S., Bilezikian, J., Binkley, N., Cauley, J., Compston, J., Dawson-Hughes, B., Fuleihan, G. 2011. Interpretation and use of FRAX in clinical practice - position paper of the International Osteoporosis Foundation and the International Society for Clinical Densitometry. Osteoporosis International. 22:2395-2411.

Technical Abstract: The International Osteoporosis Foundation (IOF) and the International Society for Clinical Densitometry (ISCD) appointed a joint Task Force to develop resource documents in order to make recommendations on how to improve FRAX and better inform clinicians who use FRAX. The Task Force met in November 2010 for 3 days to discuss these topics, which form the focus of this review. Review of resource documents and joint position statements of ISCD and IOF. Details on the clinical risk factors currently used in FRAX are provided and the reasons for the exclusion of others are provided. Recommendations are made for the development of surrogate models where country-specific FRAX models are not available. The wish list of clinicians for the modulation of FRAX is large, but in many instances these wishes cannot presently be fulfilled; however, an explanation and understanding of the reasons may be helpful in translating the information provided by FRAX into clinical practice.