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ARS Home » Pacific West Area » Albany, California » Western Regional Research Center » Produce Safety and Microbiology Research » Research » Publications at this Location » Publication #271812
Title: Hybrid speciation in agricultural Campylobacter coli

Author
item SHEPPARD, SAMUAL - University Of Oxford
item DIDALOT, XAVIER - University Of Oxford
item JOLLEY, KIETH - University Of Oxford
item DARLING, AARON - University Of California
item KELLEY, DAVID - University Of Sheffield
item COLLES, FRANCIS - University Of Oxford
item CODY, ALLISON - University Of Oxford
item STRACHAN, NORVAL - University Of Aberdeen
item OGDEN, IAN - University Of Aberdeen
item FORBES, KEN - University Of Aberdeen
item FRENCH, NIGEL - Massey University
item CARTER, PHILIP - Institute Of Environmental Science And Research
item Miller, William - Bill
item MCCARTHY, NOEL - University Of Oxford
item OWEN, ROBERT - Health Protection Agency
item LITRUP, EVA - Staten Serum Institute
item EGHOLM, MICHAEL - Pall Corporation
item AFFOURTIT, JASON P - Ion Torrent
item BENTLEY, STEVEN - Sanger Institute
item PARKHILL, JULIAN - Sanger Institute
item MAIDEN, MARTIN - University Of Oxford
item FALUSH, DANIEL - University College Cork

Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 8/10/2011
Publication Date: N/A
Citation: N/A

Interpretive Summary:

Technical Abstract: Introduction Hybridization between distantly related organisms can facilitate rapid adaptation but is constrained by epistatic fitness interactions. The zoonotic pathogens Campylobacter coli and C. jejuni differ from each other at an average of nearly 40 amino acids per gene. Nevertheless, they have started to exchange substantial amounts of DNA. Results By analyzing whole genome data from 200 Campylobacter isolates our results describe how a C. coli diversified into three clades that could be considered different species. The clade 1 C. coli lineage has successfully colonized the agricultural niche. Descendants fall into two groups, the ST-828 and ST-1150 clonal complexes both of which have been progressively accumulating C. jejuni DNA. The 1150 complex is less common among genotyped isolates but has undergone a substantially greater amount of introgression, leading to replacement of up to 23% of the C. coli core genome as well as import of novel DNA. By contrast, 828 complex strains have 10-11% introgressed DNA and C. jejuni and non-agricultural C. coli strains each have less than 2%. Conclusions These findings highlight the importance of recombination in pathogen emergence and shows remarkable interchangeability of basic cellular machinery even after a prolonged period of independent evolution.