|Xu, Min -|
|Zhang, Ying-Jun -|
|Li, Xing-Cong -|
|Jacob, Melissa -|
|Yang, Chong-Ren -|
Submitted to: Journal of Natural Products
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: August 10, 2010
Publication Date: August 18, 2010
Citation: Xu, M., Zhang, Y., Li, X., Jacob, M.R., Yang, C. 2010. Steroidal saponins from fresh stems of Dracaena angustifolia. Journal of Natural Products. 73:1524-1528. Interpretive Summary: This manuscript describes the isolation and structure elucidation of six new steroidal saponins from the plant Dracaena angustifolia. Two compounds showed antifungal activity against Cryptococcus neoformans. The manuscript will be submitted to Journal of Natural Products for publication.
Technical Abstract: Six new steroidal saponins (1-6), angudracanosides A-F, were isolated from fresh stems of Dracaena angustifolia, together with eight known compounds. The structures of compounds 1-6 were determined by detailed spectroscopic analyses and chemical methods. Antifungal testing of all compounds showed that 6 and 7 were active against Cryptococcus neoformans with IC50s of 9.5 and 20.0 µg/mL, respectively.