Title: Potential impact of mature adipocyte dedifferentiation in terms of cell numbers Authors
|Dodson, M -|
|Guan, L -|
|Zhihua, J -|
|Du, M -|
Submitted to: International Journal of Stem Cells
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: February 11, 2011
Publication Date: N/A
Interpretive Summary: Mature fat cells may revert back to a primitive state and become capable of dividing and forming apparent new fat cells. The potential impact of mature fat cell dedifferentiation in terms of cell numbers may benefit new modalities such as tissue regeneration, may change current ideas regarding postnatal stem cells, and may be useful in a variety of applications of tissue engineering.
Technical Abstract: Mature adipocytes possess the capability to dedifferentiate and form proliferative-competent progeny cells. Little is currently known about the daughter cells, or the impact of such in vitro physiology in an in vivo situation. The present paper discusses implications of and impact of this physiology in terms of animal adiposity and composition.