Technical Abstract: Effect of Sericea lespedeza (SL; Lespedeza cuneata) leaf meal feeding was evaluated in two experiments in indoor reared goats with experimental infection of Haemonchus contortus (HC) larvae. In the first experiment, ten, 8-10 months old male kids from Spanish and Alpine cross bred, pair matched for body weight and age were fed SL or bermuda grass hay (BG; Cynodon dactylon) one week before infection and were infected with 5000 HC L3. The animals were maintained on the same diet for the remaining period and were slaughtered 28 days post-infection (DPI) to determine the establishment of incoming infective larvae. Goats fed SL had lower establishment (P < 0.05) of HC larvae than that of the control goats fed BG hay. In the second experiment, twenty five, 8-10 months old male kids of Alpine cross, Saanen, Nubian x Saanen and Spanish breeds, reared in confinement on BG were experimentally infected with 5000 HC L3. On 35 DPI, the animals were allocated to two groups after blocking by FEC, and one group was fed SL leaf meal (n = 13), and another control group remained on BG (n = 12). Four goats/group were slaughtered successively on days 7 (42 DPI), 14 (49 dpi), and 28 (63 dpi) post SL feeding, except on day 7, when five SL fed goats were slaughtered. FEC and PCV were measured at weekly intervals and worm count, female worm fecundity, worm length and mucosal eosinophils, mast cells and globule leucocytes were measured after slaughter. Goats fed SL had lower FEC (P < 0.05) one week after feeding as compared to those fed on BG, which remained at low level thereafter. Similarly, packed cell volume (PCV) was also significantly affected by treatment (P < 0.01), and treatment and time interaction (P < 0.05). However, worm burden, female worm fecundity, parasite length, and mucosal inflammatory cell count were similar between the groups.