Submitted to: Book Chapter
Publication Type: Book / Chapter
Publication Acceptance Date: September 24, 2010
Publication Date: April 13, 2012
Citation: COMBS, G.F. 2012. SELENIUM. IN:STIPANUK, M.H., CAUDILL, M.A., EDITORS. BIOCHEMICAL, PHYSIOLOGICAL, AND MOLECULAR ASPECTS OF HUMAN NUTRITION. 3RD EDITION. PHILADELPHIA, PA. SAUNDERS. 867-887. Technical Abstract: This chapter addresses the nutritional functions of selenium, including the consequences of nutritional selenium deficiency and the role of selenium in the prevention of cancer. These functions are discussed in terms of the absorption and metabolism of dietary selenium, with special focus on the selenoenzymes and their synthesis involving the cotranslational incorporation of selenium as the unique selenoamino acid selenocysteine.