Technical Abstract: While a relative latecomer to the post-genomics era of functional biology, the application of mass spectrometry-based proteomic analysis has increased exponentially over the past 10 years. Some of this increase is the result of transition of chemists physicists, and mathematicians to the study of biology, and some is due to improved methods, increased instrument sensitivity, and better techniques of bioinformatics-based data analysis. Proteomic analyses have transcended their initial purely descriptive applications and are now being employed extensively in studies of post-translational protein modifications, protein interactions, and study of metabolic networks. Herein we review the results from application of proteomics-based research approaches to study angiosperm reproduction, from flowers to seeds, and speculate on future directions. Additionally,apomixis is mentioned briefly as an aspect of plant reproduction that remains poorly understood.