Technical Abstract: Hamsters or mice are often anesthetized when they are used as the hosts for insect feeding experiments. An experiment was done to determine if there was a difference in mosquito blood feeding success when fed on hamsters anesthetized using two commonly used protocols. The number of blood-fed females was determined for three genera of mosquitoes using Anopheles quadrimaculatus, Aedes aegypti, and Culex tarsalis fed on hamster anesthetized with ketamine alone or ketamine plus xylazine. This study found that for Aedes aegypti, ketamine alone resulted in a 6 fold increase in proportion of mosquitoes blood-fed, but due to large variability this failed to reach significance with the number of mosquitoes used. Further investigation with more mosquitoes will be needed to determine if this is indeed significant.