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ARS Home » Southeast Area » Little Rock, Arkansas » Microbiome and Metabolism Research Unit » Research » Publications at this Location » Publication #249719
Title: Antioxidant capacities of seven flavonoid compounds isolated from pulp of acai fruit (Euterpe oleracea)

Author
item KANG, JIE - Arkansas Children'S Nutrition Research Center (ACNC)
item LI, ZHIMIN - Shanghai Institute Of Pharmaceutical Industry
item WU, TONG - Shanghai Institute Of Pharmaceutical Industry
item JENSEN, GITTE - Nis Labs
item SCHAUSS, ALEXANDER - Aibmr Life Sciences (AMERICAN INSTITUTE FOR BIOSOCIAL AND MEDICAL RESEARCH)
item WU, XIANLI - Arkansas Children'S Nutrition Research Center (ACNC)

Submitted to: Journal of Federation of American Societies for Experimental Biology
Publication Type: Abstract Only
Publication Acceptance Date: 3/15/2010
Publication Date: 4/12/2010
Citation: Kang, J., Li, Z., Wu, T., Jensen, G.S., Schauss, A.G., Wu, X. 2010. Antioxidant capacities of seven flavonoid compounds isolated from pulp of acai fruit (Euterpe oleracea) [abstract]. Journal of Federation of American Societies for Experimental Biology. Journal of Federation of American Societies for Experimental Bilogy. 24:921.8.

Interpretive Summary:

Technical Abstract: The pulp of açai fruit (Euterpe oleracea Mart.) has been demonstrated to exhibit extremely high antioxidant capacity. Seven major flavonoids were isolated from freeze-dried acai pulp by various chromatographic methods. Their structures were elucidated as orientin (1), homoorientin (2), vitexin (3), luteolin (4), chrysoeriol (5), quercetin (6), and dihydrokaempferol (7) by NMR, MS and compared to authentic standards. Antioxidant capacities of these flavonoids were evaluated by the following assays: oxygen radical absorbance capacity (ORAC); cell-based antioxidant protection in erythrocyte (CAP-e); ROS formation in polymorphonuclear granulocytes (ROS PMN). ORAC values varied widely (1,423.6 – 14,817.4 micro-mol TE/g) among the seven compounds based on numbers and positions of hydroxyl groups and/or substitute groups. The ORAC values of aglycones were generally higher than that of glycosides. CAP-e results indicated that three compounds (4, 6, 7) could enter the cytosol and significantly reduce oxidative damage within living cells. ROS PMN assay showed four compounds (2, 3, 7, 6) had exceptional anti-inflammatory properties in reducing ROS formation in PMN cells, even when high amounts of ROS were produced upon hydrogen peroxide administration.