ARS | Publication request: Dietary vitamin K guidance: an effective strategy for stable control of oral anticoagulation?

Submitted to: Nutrition Reviews
Publication Type: Review Article
Publication Acceptance Date: December 21, 2009
Publication Date: March 1, 2010
Citation: Booth, S.L. 2010. Dietary vitamin K guidance: an effective strategy for stable control of oral anticoagulation?. Nutrition Reviews. 68(3):178–181.

Technical Abstract: Numerous factors have been identified as risk factors for instability of oral anticoagulation, including variability in vitamin K intake. However few studies have directly tested the feasibility of manipulating dietary vitamin K to achieve stable oral anticoagulation. Recent findings from a randomized clinical trial suggest that dietary vitamin K manipulation is a viable option for managing stability of oral anticoagulant therapy. The approach appears to be effective for those patients who are under-anticoagulated, and consume a small number of vitamin K-rich food sources. While an encouraging option for management of warfarin therapy, longer-term studies in different patient populations are required.