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United States Department of Agriculture

Agricultural Research Service

Research Project: ENHANCING ANIMAL WELL-BEING, IMMUNOCOMPETENCE, AND PERFORMANCE IN SWINE AND BEEF CATTLE Title: Oral administration of Saccharomyces cerevisiae boulardii reduces Escherichia coli endotoxin associated mortality in weaned pigs

Authors
item Collier, Chad
item Carroll, Jeffery
item Starkey, Jessica -
item Sparks, John -

Submitted to: American Society of Animal Science Southern Section Meeting
Publication Type: Abstract Only
Publication Acceptance Date: November 2, 2009
Publication Date: May 14, 2010
Citation: Collier, C.T., Carroll, J.A., Starkey, J., Sparks, J. 2010. Oral administration of Saccharomyces cerevisiae boulardii reduces Escherichia coli endotoxin associated mortality in weaned pigs [abstraxt]. Southern Section of American Society of Animal Science, Feb 7-10, 2010, Orlando, FL. Journal of Animal Science. 88(E-Supplement 3):#59.

Technical Abstract: The effects of active dry yeast, Saccharomyces cerevisiae boulardii (Scb), on the immune/neuroendocrine response and subsequent mortality to E. coli lipopolysaccharide (LPS) administration were evaluated in newly weaned pigs (26.1 + or - 3.4 d of age). Barrows were assigned to 1 of 2 treatment groups; with (Scb; n = 15) and without (Control; n = 15) the in-feed inclusion of Scb (200g/ton) for 16 d. On d 16, all pigs were dosed via indwelling jugular catheters with LPS (25 ug/kg BW) at 0 h. Serial blood samples were collected at 30-min intervals from -1 h to 6 h and then 24 h. Differential blood cell populations were enumerated hourly from 0 h to 6 h and at 24 h. Serum cortisol, interleukin-1 beta (IL-1), IL-6, tumor necrosis factor-alpha (TNF) and interferon-gamma (IFN) concentrations were determined via porcine-specific ELISAs at all time points. In Scb-treated pigs, ADG increased (P < 0.05) by 39.9% and LPS-induced pig mortality was reduced 20% compared to Control pigs. White blood cells, lymphocytes, and neutrophils were increased (P < 0.05) in Scb-treated animals prior to LPS dosing compared to Controls before being equally suppressed (P < 0.05) from baseline in both treatments after LPS dosing with a return to baseline by 24 h. Cortisol suppression (P < 0.05) was observed in Scb-treated piglets from -1 h to 1 h relative to LPS dosing compared to Controls before both peaked equally and subsequently returned to baseline. Peak production (P < 0.05) of IL-1 and IL-6 was lower in Scb-treated pigs after LPS administration compared to Controls before both equally returned to baseline. Peak TNF production in Scb-treated animals was accelerated 0.5 h and was greater (P < 0.05) than peak production in Controls after which both equally returned to baseline. The peak production of IFN was greater and had increased (P < 0.05) amplitude persistent for 3 h in Scb-treated animals compared to Controls before both equally returned to baseline. These results highlight the previously unidentified effects of Scb administration on immune and neuroendocrine responses and the subsequent impact on growth and endotoxin-induced mortality.

Last Modified: 10/24/2014
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