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United States Department of Agriculture

Agricultural Research Service

Research Project: DISCOVERY AND DEVELOPMENT OF NATURAL PRODUCTS FOR PHARMACEUTICAL AND AGRICHEMICAL APPLICATIONS

Location: Natural Products Utilization Research

Title: Clerodane and Ent-kaurane Diterpene Glycosyl and Glycoside Derivatives from the Leaves of Casearia sylvestris

Authors
item Wang, Wei -
item Ali, Zulfiqar -
item Li, Xing-Cong -
item Khan, Ikhlas -

Submitted to: Helvetica Chimica Acta
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: August 19, 2009
Publication Date: August 31, 2009
Citation: Wang, W., Ali, Z., Li, X., Khan, I.A. 2009. Clerodane and Ent-kaurane Diterpene Glycosyl and Glycoside Derivatives from the Leaves of Casearia sylvestris. Helvetica Chimica Acta. 92:1829-1839.

Interpretive Summary: Casearia sylvestris Swartz (Flacourtiaceae) is a Brazilian and Paraguayan folk medicinal plant called as “Guaçatonga” or “Chá de Bugre” and used to treat snakebite, trauma, ulceration, obesity, and cough. Our continued investigation of this species has led to identification of five new clerodane diterpene glycosides, caseariasides A-E (1-5) and three ent-kaurane diterpene glucosides, sylvestrisides C-E (6-8). Here, we report the isolation and structure elucidation of these eight new glycosides.

Technical Abstract: Five new clerodane diterpene glycosides caseariasides A-E (1-4) and three new ent-kaurane diterpene glucosides sylvestrisides C-E (6-8) were isolated from the leaves of Casearia sylvestris. Their structures were determined on the basis of chemical and spectroscopic analyses.

Last Modified: 9/1/2014
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