Technical Abstract: An analytical method was developed using ultra performance liquid chromatography-triple quadrupole-tandem mass spectrophotometry (UPLC-TQ-MS/MS) to simultaneously analyze 14 sulfonamides (SA) in six minutes. The instrumental detection limit based on signal-to-noise ratio (S/N) > 3, was below 1 pg/µL (5 pg on column) for all SAs except sulfachloropyridazine. Surface water, ground water, soil, slurry manure contained in storage ponds in and around swine [Sus scrofa domesticus] rearing facilities were analyzed. Sample cleanup for ground water and surface water included using solid phase extraction using Oasis' hydrophilic-lipophilic balance (HLB) cartridges. The soil and slurry manure required tandem strong anion exchange (SAX) and HLB solid phase extraction cartridges for sample cleanup. With few exceptions, the recoveries ranged from 60 - 100 % for all matrices. The coefficient of variation (CV) was within 20% for most of the compounds analyzed. Using this method, sulfamethazine concentrations of 2250 – 5060 ng/L, sulfamethoxazole concentrations of 108 – 1.47 ' 106 ng/L, and sulfathiazole concentrations of 785 – 1700 ng/L were found in the slurry manure. Sulfadimethoxine (2.0 – 32 ng/L), sulfamethazine (2.0 – 5.1 ng/L), and sulfamethoxazole (20.5 – 43.0 ng/L) were found in surface water and ground water. In top soil (0-15.2 cm), sulfamethazine ranged 34.5 – 663 ng/kg dry weight in those locations that received slurry manure as a nutrient; no SAs were found in the soil depths between 45.7 – 61.0 cm.