|Ali, Zulfiqar -|
|Khan, Shabana -|
|Khan, Ikhlas -|
Submitted to: Planta Medica
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: November 20, 2008
Publication Date: March 29, 2009
Repository URL: http://www.thieme-connect.de/ejournals/toc/plantamedica
Citation: Ali, Z., Khan, S.I., Khan, I.A. 2009. Soyasaponin Bh, a Triterpene Saponin Containing a Unique Hemiacetal-Functional Five-Membered Ring from Glycine max (Soybeans). Planta Medica. 75:371-374. Interpretive Summary: This was a phytochemical study on soybeans which is a dietary source of saponins. A new compound was isolated alongwith other known compounds and structure was determined. The biological activity of isolated compounds was tested to see if they have any anticancer and estrogenic potential.
Technical Abstract: Soybeans (Glycine max L. Merill) and soy-based food products are major dietary sources of saponins. An oleanane triterpenoid saponin, soyasaponin Bh (1) containing a unique five-membered ring with a hemiacetal functionality together with seven known saponins were isolated from soybeans. Their structures were determined by chemical and spectroscopic analyses including HRESI- MS, 1D- and 2D-NMR. None of the isolated saponins showed any anti-cell proliferative activity in tumor cell lines. Soysaponin I showed a weak estrogenic effect in the yeast estrogen screen (YES) assay.