Skip to main content
ARS Home » Southeast Area » Oxford, Mississippi » Natural Products Utilization Research » Research » Publications at this Location » Publication #242845
Title: Puupehanol, a Sesquiterpene-Dihydroquinone Derivative from the Marine Sponge Hyrtios sp

Author
item XU, WEN-HUI - Northwest Agricultural & Forestry University
item DING, YUANQING - University Of Mississippi
item JACOB, MELISSA - University Of Mississippi
item AGARWAL, AMEETA - University Of Mississippi
item CLARK, ALICE - University Of Mississippi
item FERREIRA, DANEEL - University Of Mississippi
item LIANG, ZONG-SUO - Northwest Agricultural & Forestry University
item LI, XING-CONG - University Of Mississippi

Submitted to: Bioorganic and Medicinal Chemistry Letters
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 9/4/2009
Publication Date: 9/11/2009
Citation: Xu, W., Ding, Y., Jacob, M.R., Agarwal, A.K., Clark, A.M., Ferreira, D., Liang, Z., Li, X. 2009. Puupehanol, a Sesquiterpene-Dihydroquinone Derivative from the Marine Sponge Hyrtios sp. Bioorganic and Medicinal Chemistry Letters. 19:6140-6143.

Interpretive Summary: This manuscript describes the isolation and structure elucidation of a new sequiterpene-dihydroquinone compound and the antifungal activity of two known compounds from a marine sponge, Hyrtios sp.

Technical Abstract: Puupehanol (1), a new sesquiterpene-dihydroquinone derivative, was isolated from the marine sponge Hyrtios sp., along with the known compounds puupehenone (2) and chloropuupehenone (3). The structure of 1 was established as (20R,21R)-21-hydroxy-20,21-dihydropuupehenone by interpretation of spectroscopic data and experimental and calculated electronic circular dichroism spectra. Compounds 2 and 3 are the active constituents responsible for the antifungal activity observed in the crude extract. In particular, compound 2 exhibited potent activity against Cryptococcus neoformans and Candida krusei with MFCs of 1.25 and 2.50 µg/mL, respectively.