Technical Abstract: Because of a long tradition of use in humans, botanicals have many unique advantages to offer as sources of natural products with pharmaceutical influence, especially in terms of opportunities for the development of diverse botanical products. This chapter outlines their use in screening programs, including distinctive informatics needs and certain paths/modes of development inherent to botanicals vs other sources of natural product leads. The uses of botanical derived products continues to change and grow from the traditional medicinal uses to nutraceutical use, dietary supplements, "functional foods", food additives, "sports and energy" food/drinks and drugs (both small molecules and complex mixtures). The perspectives and goals of practitioners of botanical research are quite diverse. Many research groups seeking to identify particular activities in plant extracts have adopted the technology developed in the pharamaceutical companies for empirical discovery, high throughput screening and its data management underpinning.