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ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #242455
Title: Vitamin E transport gene variants and prostate cancer

Author
item ZINGG, JEAN-MARC - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item AZZI, ANGELO - Jean Mayer Human Nutrition Research Center On Aging At Tufts University

Submitted to: Cancer Research
Publication Type: Other
Publication Acceptance Date: 6/15/2009
Publication Date: 8/15/2009
Citation: Zingg, J., Azzi, A. 2009. Vitamin E transport gene variants and prostate cancer. Cancer Research. 69:6756.

Interpretive Summary:

Technical Abstract: In the February 15, 2009 issue of Cancer Research, Wright et al. investigated whether polymorphisms in two vitamin E transport genes are associated with elevated prostate cancer risk resulting from altered plasma vitamin E concentrations. However, the circulating vitamin E level is influenced by many genes and thus the observed associations may not necessarily reflect the function of the two analyzed genes. The expression level and activity of these genes in peripheral tissues such as prostate, and the consequent local levels and molecular action of vitamin E may be more relevant for influencing the prostate cancer risk. The observed association of gene polymorphisms of vitamin E transport genes and prostate cancer risk is interesting, but without further basic research into the function of these genes, a link to circulating vitamin E levels remains elusive.