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United States Department of Agriculture

Agricultural Research Service

Research Project: DISCOVERY AND DEVELOPMENT OF NATURAL PRODUCTS FOR PHARMACEUTICAL AND AGRICHEMICAL APPLICATIONS

Location: Natural Products Utilization Research

Title: Lanostane-Type Triterpenes from the Mushroom Astraeus pteridis with Antituberculosis Activity

Authors
item Stanikunaite, Rita -
item Radwan, Mohamed -
item Trappe, James -
item Fronczek, Frank -
item Ross, Samir -

Submitted to: Journal of Natural Products
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: October 1, 2008
Publication Date: December 9, 2008
Citation: Stanikunaite, R., Radwan, M.M., Trappe, J.M., Fronczek, F., Ross, S.A. 2008. Lanostane-Type Triterpenes from the Mushroom Astraeus pteridis with Antituberculosis Activity. Journal of Natural Products. 71(12):2077-2079.

Interpretive Summary: Three new and two known lanostane triterpenes had been isolated and chemically identified from the Truffle mushroom Astraeus pterdis. The antituberculosis activity of the isolates was evaluated.

Technical Abstract: Bioassay-guided fractionation of the EtOH extract of the Truffle-mimiking mushroom Astraeus pteridis led to the isolation and identification of three new (3-5) and two known (1, 2) lanostane triterpenes, and phenylalanine betaine (6). The structures of the isolates were elucidated based on 1D and 2D NMR spectroscopic data, HRESIMS results, and X-ray crystallographic analysis. The antituberculosis activity of the isolates was evaluated. Compounds 5 and 1 showed moderate antituberculosis activity with MIC values of 34.0 and 58.0 µg/mL, respectively.

Last Modified: 8/27/2014
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