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ARS Home » Southeast Area » Oxford, Mississippi » Natural Products Utilization Research » Research » Publications at this Location » Publication #241402
Title: Lanostane-Type Triterpenes from the Mushroom Astraeus pteridis with Antituberculosis Activity

Author
item STANIKUNAITE, RITA - University Of Mississippi
item RADWAN, MOHAMED - University Of Mississippi
item TRAPPE, JAMES - Oregon State University
item FRONCZEK, FRANK - Louisana State University
item ROSS, SAMIR - University Of Mississippi

Submitted to: Journal of Natural Products
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 10/1/2008
Publication Date: 12/9/2008
Citation: Stanikunaite, R., Radwan, M.M., Trappe, J.M., Fronczek, F., Ross, S.A. 2008. Lanostane-Type Triterpenes from the Mushroom Astraeus pteridis with Antituberculosis Activity. Journal of Natural Products. 71(12):2077-2079.

Interpretive Summary: Three new and two known lanostane triterpenes had been isolated and chemically identified from the Truffle mushroom Astraeus pterdis. The antituberculosis activity of the isolates was evaluated.

Technical Abstract: Bioassay-guided fractionation of the EtOH extract of the Truffle-mimiking mushroom Astraeus pteridis led to the isolation and identification of three new (3-5) and two known (1, 2) lanostane triterpenes, and phenylalanine betaine (6). The structures of the isolates were elucidated based on 1D and 2D NMR spectroscopic data, HRESIMS results, and X-ray crystallographic analysis. The antituberculosis activity of the isolates was evaluated. Compounds 5 and 1 showed moderate antituberculosis activity with MIC values of 34.0 and 58.0 µg/mL, respectively.