Technical Abstract: The objective of this paper is to present a unique formulation methodology for designing experiments to evaluate the effectiveness of a precision agricultural practice on a research farm field. We demonstrate an efficient method of combining the georeferenced treatment structure and the georeferenced design structure that describe and are necessary for the analysis of the site-specific experiment. Covariates included in this methodology are one or more layers of information (obtained by various remote-sensing systems) that geographically describe the topography of the research field and/or its crop attributes. This information also defines the geographical zones of a field where one or several rates (levels) of site-specific treatments can be assigned. The effectiveness of site-specific practices on yield in each zone are evaluated by a geographically-based statistical analysis. Concepts are illustrated using a simplistic hypothetical field. Current limitations are also discussed.