Technical Abstract: Agricultural production of food, feed, fiber or fuel is a local human activity with global ecological impacts, including the potential to foster invasions. Agriculture plays an unusual role in biological invasions, in that it is both a source of non-indigenous invasive species (NIS) and especially susceptible to invasions. A formerly innocuous species may become invasive when its environment no longer constrains its population expansion, either due to geographic dislocation or a change in its local environment. Agriculture results in both types of environmental changes, thereby driving invasions by NIS and causing other species to become “native invaders”. Preventing agricultural invaders is considered the best strategy for reducing their impacts on both agriculture and natural ecosystems. This should involve careful screening of new crop species and varieties for potential invasiveness, as well as to assure that insects and diseases are not introduced along with crop material. There is much scope for managing agricultural systems to reduce the opportunity for invasion, the impacts of invaders and the invaders that agricultural systems supply to natural areas. These include: improved sanitation to prevent transport of propagules from one field to another, improved monitoring to facilitate early detection and eradication/containment or invaders, and increasing crop and landscape diversity to improve biotic resistance to invaders.