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ARS Home » Plains Area » Manhattan, Kansas » Center for Grain and Animal Health Research » ABADRU » Research » Publications at this Location » Publication #238711
Title: Exogenous or L-Rhamnose-Derived 1,2-Propanediol Is Metabolized via a pduD-Dependent Pathway in Listeria innocua

Author
item XUE, JUNFENG
item Murrieta, Charles
item RULE, DANIEL
item MILLER, KURT

Submitted to: Applied and Environmental Microbiology
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 9/16/2008
Publication Date: 9/19/2008
Citation: Xue, J., Murrieta, C.M., Rule, D.C., Miller, K.W. 2008. Exogenous or L-rhamnose-derived 1,2-propanediol is metabolized via a pduD-dependent pathway in Listeria innocua. Applied and Environmental Microbiology. Vol. 74, pg 7073-7079

Interpretive Summary: Listeria monocytogenes is the causative agent of Listeriosis, a serious foodborne illness. Due to its pathogenicity and inherent challenges to study in the laboratory, the non-pathogenic strain, Listeria innocua, is used as a study model for Listeria monocytogenes in the laboratory. This study examines the metabolism pathways of Listeria innocua in the presence of the sugar, Rhamnose. Because metabolism is very similar between both Listeria strains, this study has allowed us to further understand the metabolism of the pathogenic Listeria monocytogenes strain which will further the understanding of the food-borne illness, Listeriosis.

Technical Abstract: 1,2-Propanediol (1,2-PD) added exogenously to cultures or produced endogenously from L-rhamnose is metabolized to n-propanol and propionate in Listeria innocua Lin11. The pduD gene, which encodes a diol dehydratase ß subunit homolog, is required for 1,2-PD catabolism. pduD and 16 other genes within the pduA-to-pduF region of a large gene cluster are induced in medium containing 1,2-PD.