NEWCASTLE DISEASE EPIDEMIOLOGY, PATHOGENESIS, AND CONTROL
Location: Exotic and Emerging Avian Viral Diseases Research Unit
Title: A highly virulent strain of Newcastle disease virus elicits a strong innate response and nitric oxide production in chickens
Submitted to: American Association of Avian Pathologists
Publication Type: Abstract Only
Publication Acceptance Date: December 20, 2008
Publication Date: May 8, 2009
Citation: Rue, C.A., Susta, L., Brown, C.C., Kapczynski, D.R., Miller, P.J., King, D.J., Suarez, D.L., Afonso, C.L. 2009. A highly virulent strain of Newcastle disease virus elicits a strong innate response and nitric oxide production in chickens [abstract]. American Association of Avian Pathologists Annual Meeting, July 11-14, 2009, Seattle, Washington. p. 16.
The avian immune response to Newcastle disease virus (NDV) and the contribution of this response to disease are not well understood. In this study, the transcriptional host response of chickens to a virulent NDV outbreak strain (California 2002) was characterized in vivo. Using microarray, a strong host response was observed in spleens at early times post-infection with the induction of numerous innate anti-viral and pro-inflammatory response genes. The robust host response to NDV shown here, in conjunction with severe pathological damage observed, suggest that the host response itself may significantly contribute to the rapid mortality of this outbreak strain.