Technical Abstract: Human beings have radically altered agricultural landscapes, establishing a limited repertoire of plants and animals over vast expanses. Here, I consider what impact such a history may have had on the distribution and diversity of animal parasite, hypothesizing that certain parasites may have been 'inadvertently domesticated.' Recent findings comparing the parasites of wildlife and domesticated hosts are reviewed from this perspective, including species of Trichinella, Taenia, Toxoplasma, and Sarcocystis. As predicted, parasites of abundant and broadly distributed livestock hosts evidently harbor exceptionally little genetic variability. By posing this question and illustrating the means for its critical evaluation, I hope to engender further exploration of the human impact on parasite evolutionary ecology.