Technical Abstract: The national call to assess effects of conservation requires wetland profiles reflect current and long-term natural variability, which poses a significant challenge for over 3 million wetlands located in the U.S. portion of the Prairie Pothole Region (PPR). One of the conservation goals in the PPR is restoration or preservation of natural ecosystem functions associated with changes in wetland cover. These seasonal and annual changes in vegetation and open water are coupled to climate and are described as the cover cycle. The cover cycle includes periods of time where high waters drown hydric vegetation during deluge and periods where hydric vegetation expands as waters dry-down during drought. Cover cycle dynamics contribute to a rich diversity of habitats that support more waterfowl than any other region in North America. Synoptic data indicative of cover cycle stage and return time would scaffold large-scale investigations of ecosystems services, habitat status, and sensitivity to climate change. This paper describes application of previously developed tools for synoptic delineation of wetland water and hydric vegetation cover to classify cover cycle for thousands of wetland basins within a single satellite image (10,000-30,000 km2 of land area). Using satellite data layers in geographic information systems (GIS), wetland profiles developed using current (2007) wetland cover data are compared with profiles developed using National Wetland Inventory (NWI) data from 1980. Results underscore the dynamic nature of these ecosystems and the need for current observations when setting conservation goals, monitoring restoration effectiveness, and evaluating anthropogenic impacts.