ARS | Publication request: Frequency of multiple serotype 1 Marek's disease virus strains in feather follicle epithelium and tumor cells following superinfection

Submitted to: American Veterinary Medical Association Abstract
Publication Type: Abstract Only
Publication Acceptance Date: January 30, 2008
Publication Date: July 19, 2008
Citation: Dunn, J.R., Witter, R.L., Silva, R.F., Lee, L.F. 2008. Frequency of multiple serotype 1 Marek's disease virus strains in feather follicle epithelium and tumor cells following superinfection [abstract]. American Veterinary Medical Association Convention Notes. 145th AVMA Annual Convention, July 19-22, 2008, New Orleans, LA. 2008 CD-ROM.

Technical Abstract: This study was designed to determine what effect multiple virulent Marek’s disease viruses have on each other during superinfection. Serotype 1 viruses able to be differentiated were administered either simultaneously or with a short (24 hours) or long (13 days) interval and virus frequency was measured in each sample. The short interval and simultaneous dual-infection both led to mixed infections or random domination by either virus in virus shedding and in tumors. In contrast, the first virus dominated after the long interval in both virus shed and in tumors except, interestingly, in the tumors from one virus pair in which the second virus was dominant in some birds.