ARS | Publication request: Analysis of the biologic differences between porcine circovirus type 2 Group-1 and Group-2 viruses

Submitted to: International Congress of Virology
Publication Type: Abstract Only
Publication Acceptance Date: August 10, 2008
Publication Date: August 10, 2008
Citation: Cheung, A.K. 2008. Analysis of the Biologic Differences Between Porcine Circovirus Type 2 Group-1 and Group-2 Viruses [abstract]. International Congress of Virology. Paper No. VOP-52. p. 37.

Technical Abstract: Phylogenetically, porcine circovirus type 2 (PCV2) isolates have been divided into two subgroups: Group-1 and Group-2. Although the genomic nucleotide sequences of Group-1 and Group-2 viruses differ by less than 5 percent, distinct amino acid residue motifs have been noted in the coding sequences of the Rep, Cap and ORF3 genes of their respective genomes. At a particular location of the gene, a certain amino acid residue or sequence is preferred. Whether there are any biological differences between Group-1 and Group-2 viruses has not been reported. Here, we showed that the excision of viral genomes in bacteria, production of infectious virions and localization of the viral antigens differ between the two PCV2 subgroups.