Submitted to: Nutrition in the Prevention and Treatment of Disease
Publication Type: Book / Chapter
Publication Acceptance Date: December 15, 2007
Publication Date: March 1, 2008
Citation: Ordovas, J.M. 2008. Genetic Influences on Blood Lipids and Cardiovascular Risk. In: Coulston, A., Boushey, C., editors. Nutrition in the Prevention and Treatment of Disease. 2nd Edition. Elsevier. p.485-513. Technical Abstract: Changes in diet are likely to modulate cardiovascular disease risk, but after decades of active research and heated discussion the question still remains: what is the optimal diet to achieve this elusive goal? A well-known phenomenon in nutrition research and practice is the dramatic variability in interindividual response to any type of dietary intervention. There are many factors influencing response, including age, sex, physical activity, alcohol, and smoking as well as genetic factors that will help to identify vulnerable populations/individuals that will be benefit from a variety of more personalized and mechanistic based dietary recommendations. This approach will break with the traditional public health approach of "one size fits all." Nutrigenetics research has begun to identify subgroups of individuals who benefit more from a low fat diet, whereas others appear to benefit more from a high monounsaturated or specific polyunsaturated fat diets. The continuous progress in Nutrigenomics will allow us to identify those persons for whom diet plays no major role in their risk of CVD as well as those persons who may benefit from specific gene-based dietary advice.